• Dr. Dave

COVID: Ibuprofen (Motrin/Advil/Aleve) - is it safe to use?

Early in the pandemic (March-April 2020) there was mass hysteria about Ibuprofen increasing the severity of COVID infections. This was theorized based on its effect on the Renin-Angiotensis-Aldosterone System (RAAS) where it causes an increase

in ACE-2 protein. Ace-2 had been found to be an important component of SARS-CoV2 entrance into cells.

There was also anecdotal stories of severe infections worsened by Ibuprofen use. This is medical speak to say that there may be some association between Ibuprofen and COVID infections.

With the benefit of hindsight and further research this has not been borne out. Some studies show that Ibuprofen may actually be beneficial in treating COVID related lung damage. Regardless, there has been no clinical data that demonstrates any causative effect between Ibuprofen and COVID severity.

Tylenol (Acetaminophen) should remain the drug of choice for fever reduction, but if Motrin is needed to treat the myalgias or for additional anti-pyretic effects, there is no evidence that it should be avoided after considerable review.


Motrin appears safe to take during COVID era despite early warnings about its danger.

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